Chang-mei KE, Ning TANG, Yong HU, Quan-quan WANG


Triazole medicines are mainstream of the antifungal medicines, especially used in curing deep department fungal infections and its important intermediate is 1-(4-hydroxylphenyl)-4-(4-nitrophenyl)piperazine. As the key intermediate of antifungal medicines of new generation,it has already caused international interest. A general and convenient synthesis of 1-(4-hydroxylphenyl)-4-(4-nitrophenyl) piperazine without the use of catalyst is described.

Key words:  1-(4-hydroxylphenyl)-4-(4-nitrophenyl)piperazine; antifungal intermediate;  Triazole

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