SYNTHESIS of 1-(4-HYDROXYLPHENYL)-4-(4-NITROPHENYL)PIPERAZINE
Triazole medicines are mainstream of the antifungal medicines, especially used in curing deep department fungal infections and its important intermediate is 1-(4-hydroxylphenyl)-4-(4-nitrophenyl)piperazine. As the key intermediate of antifungal medicines of new generation,it has already caused international interest. A general and convenient synthesis of 1-(4-hydroxylphenyl)-4-(4-nitrophenyl) piperazine without the use of catalyst is described.Key words: 1-(4-hydroxylphenyl)-4-(4-nitrophenyl)piperazine; antifungal intermediate; Triazole
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