Effect of External Electric Field Upon Selected Proteogenic Amino Acids

Józef Mazurkiewicz, Piotr Tomasik


Effect of external electric field (EEF) of 0.001, 0.005 and 0.01 a.u. upon molecular energy, charge distribution and dipole moments of non-dissociated and inner salt forms of alanine (Ala), arginine (Arg), aspartic acid Asp), cysteine (Cys), glutamic acid (Gln), glycine (Gly), isoleucine (Ile), leucine (Leu), lysine (Lys), methionine (Met), ornithine (Orn), proline (Pro), serine (Ser), threonine (Thr), tryptophan (Trp), tyrosine (Tyr), and valine (Val) were studied. For that purpose HyperChem 8.0 software was used together with the AM1 method for optimization of the conformation of the molecules in a computer vacuum. Based on the effect of EEF upon the charge density localized at the nitrogen atom of the α-amino group the acids were divided into two groups. They were Group I in which EEF increased the negative charge (Ala, Gly, Ile, Leu, Lys, Met, Phe, Pro, and Thr) and Group II in which EEF induced opposite effect (Cys, Ser, Tyr and Val). Generally, an increase in the EEF strength declined energy and increased dipole moments in non-ionized amino acids and in their inner salt forms. Energy of non-dissociated forms was more negative than these of corresponding zwitterions. Orientation of the molecules in EEF strongly depended on the EEF strength.


Alanine; Arginine; Aspartic acid; Cysteine; Glutamic acid; Glycine; Isoleucine; Leucine; Lysine; Methionine; Ornithine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine

Full Text:



Aber, J. E., Arnold, S., & Garetz, B. A. (2005). Strong dc electric field applied to supersaturated aqueous glycine solution induces nucleation of the γ polymorph. Physical Review Letters, 94(14), 145503.

Ambroziak, W., & Pietruszko, R. (1993). Metabolic role of aldehyde dehydrogenase. Advances in Experimental Medicine and Biology, 328, 5-15.

Berry, M. N., Grivel, A. R., & Phillips, J. W. (1993). Hypothesis: The electrochemical regulation of metabolism. Pure and Applied Chemistry, 65, 1957-1962.

Crabb, D. W., Bosron, W. F., & Li, T. K. (1987). Ethanol metabolism. Pharmacology & Therapy, 34, 59-73.

Dutreux, D., Notermans, S., Wijtzes, T., Gongora-Nieto, H. M., Barbosa-Canovas, G. V., & Swanson, B. G. (2000). Pulsed electric fields inactivation of attached and free-living Escherichia coli and Listeria innocua under several conditions. International Journal of Food Microbiology, 54, 91-98.

Fiedurek, J. (1999). Influence of pulsed electric field on the spores and oxygen consumption of Aspergillus niger and its citric acid production. Acta Biotechnologica, 19, 179 -186.

Grosse, H. H., Bauer, E., & Berg, H. (1988). Electrostimulation during fermentation. Bioelectrochemistry and Bioenergetics, 20, 279-285.

Hancock, C. K., Yager, B. J., Falls, C. P., & Schreck, J. O. (1963). The change in the six-number as a variable in quantitative structure―reactivity correlations in esters. Journal of the American Chemical Society, 85, 1297-1299.

Harada, A., & Kataoka, K. (2003). Switching by pulse electric field of the elevated enzymatic reaction in the core of polyion complex micelles. Journal of the American Chemical Society, 125, 15306-15307.

Harrison, S. L., Barbosa-Canovas, G. V., & Swanson, B. G. (1997). Saccharomyces cerevisiae structural changes induced by pulsed electric field treatment. LWT-Food Science and Technology, 30, 236-240.

Jakubke, H. D., & Jeschkeit, H. (1973). Aminosaeuren, peptide, proteine. Berlin: Akademie-Verlag.

Mazurkiewicz, J., & Tomasik, P. (2010). Contribution to understanding of weak electrical phenomena. Natural Sciences, 2, 1195 -1202.

Mazurkiewicz, J., & Tomasik, P. (2012a). Effect of external electric field upon charge distribution, energy and dipole moment of selected monosaccharide molecules. Natural Sciences, 4, 278-285.

Mazurkiewicz, J., & Tomasik, P. (2012b). Effect of external electric field upon lower alkanols. Advances in Natural Sciences, 5(4), 28-35.

Mazurkiewicz, J., & Tomasik, P. (in press). Effect of external electric field to porphin and selected metalloporphyrin systems. Conventional and Alternative Mededicin in Science.

Nakanishi, K., Tokuda, H., Soga, T., Yoshinaga, T., & Takeda, M. (1988). Effect of electric current on growth and alkohol production by yeast cells. Journal of Fermentation and Bioengimeering, 85, 250-253.

Nechitailo, G., & Gordeev, A. (2001). Effect of artificial electric fields on plants grown under microgravity conditions. Advances in Space Research, 28, 629-631.

Pokorny, J., Hasek, J., & Jelinek, F. (2005). Endogenous electric field and organization of living matter. Electromagnetic Biology and Medicine, 24, 185-197.

Taft, R. W. Jr. (1953). The general nature of the proportionality of polar effects of the substituent groups in organic chemistry. Journal of the American Chemical Society, 75, 4231-4238.

Tiessie, J., Knox, B. E., Tsong, T. Y., & Wehrle, J. (1981). Synthesis of adenosine triphosphate in respiration-inhibited submitochondrial particles induced by microsecond electric pulses. Proceedings of the National Academy of Sciences USA, 78, 7473-7477.

Tsong, T. Y. & Astumray, R. D. (1986). Absorption and conversion of electric field energy by membrane bound aptases. Bioelectrochemistry and Bioenergetics, 15, 457-476.

DOI: http://dx.doi.org/10.3968/j.ans.1715787020130604.2716


  • There are currently no refbacks.

Share us to:   


How to do online submission to another Journal?

If you have already registered in Journal A, then how can you submit another article to Journal B? It takes two steps to make it happen:

1. Register yourself in Journal B as an Author

Find the journal you want to submit to in CATEGORIES, click on “VIEW JOURNAL”, “Online Submissions”, “GO TO LOGIN” and “Edit My Profile”. Check “Author” on the “Edit Profile” page, then “Save”.

2. Submission

Go to “User Home”, and click on “Author” under the name of Journal B. You may start a New Submission by clicking on “CLICK HERE”.

We only use the following emails to deal with issues about paper acceptance, payment and submission of electronic versions of our journals to databases:
caooc@hotmail.com; office@cscanada.net; office@cscanada.org

 Articles published in Advances in Natural Science are licensed under Creative Commons Attribution 4.0 (CC-BY).


Address: 9375 Rue de Roissy Brossard, Québec, J4X 3A1, Canada

Telephone: 1-514-558 6138
Website: Http://www.cscanada.net; Http://www.cscanada.org
E-mail:caooc@hotmail.com; office@cscanada.net

Copyright © 2010 Canadian Research & Development Centre of Sciences and Cultures