Antiasthmatic Effect of Standardized Extract of Ayurvedic Compounds via Nasal Spray Actuation (in Aerosol Form) in Rodents and Its Comparative Clinical Study

Kajaria Divya, J. S. Tripathi, J. K. Samaria, S. K. Tiwari

Abstract


Abstract
Asthma is one of the most prevalent chronic inflammatory lung disease among children and adults. Morbidity and mortality rate of asthma is raising at the rate of 10% every year inspite of availability of contemperory modern medicines. Studies show that presently majority of world population are using complementory and altenative medicines for the management of bronchial asthma. Ayurveda (Indian system of medicine) is the most popular and widely used alternative medicine. Extensive and proficient researches in the field of Ayurveda validate its efficay in the mangement of chronic diseases including asthma. The present study was designed to search a safe and effective herbal medicine for the treatment of acute attack of Bronchial Asthma and secondary objective to expand the sphere of Ayurvedic medicine by exploring the new possibilities of drug administration techniques.Hydroethanolic extract of both the polyherbal compounds were given through nebulization and their efficacy was assessed. Results showed that all groups treated with Ayurvedic compounds had significant improvent in PFT (pulmonary function test). Cough, Expectoration and ESR is markedly reduced in group treaed with Bharangyadi Ayurvedic Nebulizer whereas Wheezing, frequency of attack and severity of attack on exposure to allergens was significantly (p < 0.001) reduced in group treated with Shirishadi Ayurvedic Nebulizer.


Keywords


Bronchial asthma; Polyherbal Ayurvedic drugs; Nebulization; PFT

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References


Tripathi, K. D. (1998). Essential of Medical Pharmacology, 26(4), 222-238.

Vishwanath, R., Prasad, M., Thakur, A. K., Sinha, S. P., Prakash, N., & Mody, R. K., et al. (1966). Epidemiology of Asthma in an Urban population: A random morbidity survey. J. Indian Med. Assoc., 46, 480-483.

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World Health Organization Bronchial Asthma. (2005). Scope of the problem: Geneva: World Health Organization. Retrieved from http//www.who.int/entity/respiratory asthma/scope/en/index htm

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DOI: http://dx.doi.org/10.3968%2F3729

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