Spectrophotometric Determination of Methyl Paraben in Pure and Pharmaceutical Oral Solution
A simple, cheap and sensitive spectrophotometric method for the determination of methyl paraben in pure and dosage form has been described. The Method is based on the diazotization of the drug by sodium nitrite in acidic medium at 5Cº followed by coupling with ortho-aminobenzoic acid to form orange color the product was stabilized and measured at 442 nm Beer’s law is obeyed in the concentration range of 1-9 μg∙ml-1 with molar absorptivity of 1.6x106 L∙mole-1∙cm-1., Sandell’s sensitivity were 0.0095 μg∙cm-1, The detection limit were 0.0065 μg∙ml-1, and The limit of Quantitation were 0.02 μg∙ml-1. All variables including the reagent concentration, reaction time, color stability period, and mole ratio were studied in order to optimize the reaction conditions. No interferences were observed Results of analysis were validated statistically and by recovery studies. These methods are successfully employed for the determination of methyl paraben in some oral solution. The developed method is easy to use and accurate for routine studies relative to HPLC and other techniques.
Aromdee, C., & Rattandon, B. (2009). Quantitative analysis of some volatile components in Mimusops elengi L. SongKlanaKarin Journal of Science and Technology, 31(3), 285-288.
Blanco, C. C., Carretero, A. S., Peinado, S. F., & Guttierrez, A. F. (2000). Michro Chimica Acta,.134, 107-111.
Boonleang, J., & Tanthana, C. (2010). Simultaneous stability-indicating hplc method for the determination of cisapride, methylparaben and propylparaben in oral suspension. Songklanakarin Journal of Scince andTecnology, 32(4), 379-385.
Dhahir, S. A., & Hussein, H. J. (2012). Spectrophotometric determination of thymol in pure and lesterine mouth washing. Tikrit Journal of Pure Science, 17(4).
Giordano, F., Bettini, R., Donini, C., Gazzaniga, A., Caira, M. R., Zhang, G. G. Z., & Grant, D. J. W. (1999). Physical properties of parabens and their mixtures: Solubility in water, thermal behavior, and crystal structures. J. Pharm. Sci., 88(11), 1210-1216.
Han, Y., Jia, X., Liu, X., Duan, T., & Chen, H. (2010). DLLME combined with GC–MS for the determination of methylparaben, ethylparaben, propylparaben and butylparaben in Beverage Samples. Chromatographya, 72(3-4), 351-355.
Kamble, R. M., Singh, S. G., & Singh, S. (2011). Simultaneous determination of preservatives (methyl paraben and propyl paraben) in sucralfate suspension using high performance liquid chromatography. E-Journal of Chemistry, 8(1), 340-346.
Kebbekus, B. B., & Mitra, S. (1998). Environmental chemical analysis. London: Blackie Academic and Professional.
Krishnachaitanya, K., Israel, D. S., & Gowrisankar, D. (2011). RP-HPLC method for the estimation of levocitrizine and its preservatives in oral solutions. International Journal of Pharma Research & Development, 3(1), 28-31.
Mannucci, C., Bertini, J., Cocchini, A., Perico, A., Salvagnini, F., & Triolo, A. (1992). Simultaneous determination of otilonium bromide and diazepam by first-derivative spectroscopy. Journal of Pharmaceutical Sciences, 81(12), 1175-1177.
Modi, P. B., Vairale, A. S., Sherikar, A. V., & Nalamothu, V. (2011). A stability indicating RP-HPLC method for simultaneous determination of oxybenzone, avobenzone, octocrylene, methylparaben, propylparaben in sunscreen formulations. IJPI’S Journal of Analytical Chemistry, 1(2), 25-35.
Mowad, C. M. (2000). Allergic contact dermatitis caused by parabens: 2 case reports and a review. Am. J. Contact Dermatol., 11, 53-56.
Saadiyah, A. D. (2011). Spectrophotometric determination of thymol in pure and pharmaceutical preparation by diazotization-coupling method with 2, 4-dichloroaniline as the coupling agent. Journal of Kufa for Chemical Science, 1(2), 99-108.
Saadiyah, A. D., Amira, H, Maha, K. S., & Rafah, K. A. (2010). Safety method, spectrophotometric determination of sulfamethaxazole drug in bulk and pharmaceutical preparations. Baghdad Science Journal, 7(1).
Shabir, G. (2010). A new validated HPLC method for the simultaneous determination of 2-phenoxyethanol, methylparaben, ethylparaben and propylparaben in a pharmaceutical gel. Indian Journal of Pharmaceutical Science, 72(4), 421-425.
Shnmugan, G., Rajendran, B., Ralhakrishnan, V., & Tao, H. (2010). GC-MS method for the determination of paraben preservatives in the human breast cancerous tissue. Michrochemical Journal, 96(2), 391-396.
Skoog, D. A., Holler, J., & Crouch, S. R. (2007). Principles of instrumental analysis (6th ed.).
Soni, M. G., Taylor, S. L., Greenberg, N. A., & Burdock, G. A. (2002). Evaluation of the health aspects of methyl paraben: A review of the published literature. Food Chem. Toxicol., 40(10), 1335-1373.
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