Comparative Double Blind Clinical Trial Study of Side Effects of Areca catechu L., TTHF, and Mebendazole, in Treatment of Human Mixed Worm Infection

Buavaroon Srichaikul, Weerasak Seubsoh, Supachai Samappito, Gordon Bakker


This study was carried out in Mahasarakham Primary Healthcare Centre, Mahasarakham province in the area of Northeastern of Thailand. The experiment was carried on with 200   samples  with  randomized control trial clinical study in order to examine the side effects of Areca catechu Linn., TTHF and  Mebendazole  after the treatment of antihelmintic activity of mixed worms infection in human . The 3 experimental groups consisted of 50 patients in each group and 50 patients for control group testing with placebo with inclusion and exclusion criteria which were screened by parasitologist of mixed worm infection symptoms samples. The investigation  of side effects were investigated after treating the first dose of Areca catechu Linn, TTHF and Mebendazole which were confirmed by the physician and the pharmacist. The side effects data were collected before and after the treatment with Areca catechu Linn. and with placebo. The result showed that Areca catechu Linn. had 20% of diarrhea and 20% of nausea, 20% of diarrhea in Mebendazole  and 0% in TTHF.
The suggestion of this study should increase the number of samples of worm infected patients and also the numbers of locations in Thailand  in order to obtain various kinds of helminthes.
Key words: TTHF (Thai Traditional  Herbal  Formula); Mebendazole; Areca catechu Linn.; Side effects; Antihelmintic activity


TTHF (Thai Traditional Herbal Formula); Mebendazole; Areca catechu Linn.; Side effects; Antihelmintic activity

Full Text:



Ajima Karphrom et al. August 2009. The ANTI – MICROBIAL ACTIVITIES OF BETEL NUT (ARECA CATECHU LINN) SEED EXTRACTS. Rajamangala University of Technology Lanna, Chiang –Mai, Thailand, 23 – 29.1
Chanchai Sardsaengjun et al. Jan. – Mar. 2010. The effect of temperature and duration time on polyphenols extract of Areca catechu Linn. Seeds. Department of Pharmacognosy, Faculty of Pharmacy, Huachiew chalermprakiet University, Samutprakarn province, Thailand, 10540, Vol. 5 No.12
Freda M. Paul et al. March, 1975. The trial of mebendazole in trichuriasis (whipworm) infestation in Singapore children. Singapore Medical Journal. Vol.16, No. 1.3
M. Albonico et al. 2003. The efficacy of mebendazole and levamisole alone or in combination against intestinal nematode infections after repeated targeted mebendazole treatment in Zanzibar. Bulletin of the World Health Organization, 814
M. Dawson et al. 1985. The effect of dose form on the bioavailability of mebendazole in man. Department of Pharmacy, The University of Sydney, Sydney, N.S.W.2006, Australia, 87 – 90, 195
Preetee Jaiswal et al. 2011.Studied the Areca catechu L. : A valuable Herbal Medicine Against Different Health Problem. Research Journal of Medicinal Plant. Department of Zoology, DDU Gorakhpur University, Gorakhpur – 273009, UP, India, 145 – 1526
Sajala kafle et al. September – October 2011.Antifertility effect of Areca catechu in male albino rats. International Journal of Pharmaceutical Sciences Review and Research, Volume 10, Issue 17.




  • There are currently no refbacks.

Copyright (c)

Share us to:   


How to do online submission to another Journal?

If you have already registered in Journal A, then how can you submit another article to Journal B? It takes two steps to make it happen:

1. Register yourself in Journal B as an Author

Find the journal you want to submit to in CATEGORIES, click on “VIEW JOURNAL”, “Online Submissions”, “GO TO LOGIN” and “Edit My Profile”. Check “Author” on the “Edit Profile” page, then “Save”.

2. Submission

Go to “User Home”, and click on “Author” under the name of Journal B. You may start a New Submission by clicking on “CLICK HERE”.

We only use the following emails to deal with issues about paper acceptance, payment and submission of electronic versions of our journals to databases:;;;

 Articles published in Advances in Natural Science are licensed under Creative Commons Attribution 4.0 (CC-BY).


Address: 9375 Rue de Roissy Brossard, Québec, J4X 3A1, Canada

Telephone: 1-514-558 6138
Website: Http://; Http://;

Copyright © 2010 Canadian Research & Development Centre of Sciences and Cultures