A Cholesterol and Actinide Dependent Shadow Biosphere of Archaea and Viroids in Chronic Renal Failure

Abstract

Aim: Endogenous digoxin has been related to the pathogenesis of chronic renal failure- chronic glomerulonephritis. The possibility of endogenous digoxin synthesis by archaea with a mevalonate pathway and cholesterol catabolism was considered.Methods: 10 cases each of chronic renal failure- chronic glomerulonephritis before starting treatment and 10 age and sex matched healthy controls from general population were chosen for the study. Cholesterol substrate was added to the plasma of the patients and the generation of cytochrome F420, free RNA, free DNA, polycyclic aromatic hydrocarbon, hydrogen peroxide, serotonin, pyruvate, ammonia, glutamate, cytochrome C, hexokinase, ATP synthase, HMG CoA reductase, digoxin and bile acids were studied. The changes with the addition of antibiotics and rutile to the patient’s plasma were also studied. The statistical analysis was done by ANOVA.Results: The parameters mentioned above were increased the patient’s plasma with addition of cholesterol substrate. The addition of antibiotics to the patient’s plasma caused a decrease in all the parameters while addition of rutile increased their levels. Conclusion: An actinide dependent shadow biosphere of archaea and viroids is described in chronic renal failure- chronic glomerulonephritis contributing to its pathogenesis.

Key words: Archaea; Viroids; Actinide; Cholesterol; Chronic renal failure