Nonlinear Genetics Inbreeding and Genetic Load

Volobuev Andrey Nikolaevich, Romanchuk Peter Ivanovich, Malishev Vladimir Kirikovich


Comparison of concepts of occurrence and accumulation of the genetic load in result of inbreeding for a family tree and a population is given. It is shown that for the population the analysis of the genetic load concerns to area of nonlinear genetics. The nonlinear differential equation of the second order being the special case of the Hardy-Weinberg law at presence inbreeding for the population is found. The numerical decision of this equation allowed to find the law of increase of recessive allele frequency in the population is given. Some aspects of the traditional theory of the genetic load are considered.


Genetic load; Inbreeding; Hardy-weinberg law; Nonlinear genetics

Full Text:



Ayala, F., & Kiger, J. J. (1984). Modern genetics (Vol.3, pp.153, 171). California: The Benjamin/Cummings Publishing Company, Inc.

Morton, N. E., Crow, J. F., & Muller, H. J. (1956). An estimate of the mutational damage in man from data on consanguineous marriages. Proc. Natl. Acad. Sci. USA, 42, 855-863.

Muller, H. J. (1950). Our load of mutation. Am. J. Hum. Genet., 2, 111-176.

Vogel, F., & Motulsky, A. (1990). Human genetics (Vol.2, p.346, 349, 351, 352, 353, 354, 358; Vol.3, p.37). Berlin: Springer-Verlag.

Volobuev, A. N., & Petrov, E. S. (2011). Modelling of the populating development of the genome in the radiation of the environment. Natural Science, 3(12), 1029-1033.

Volobuev, A. N., Romanchuk, P. I., & Malishev, V. K. (2013). Population and mutagenesis or about hardy and weinberg one methodical mistake. Advances in Natural Science, 6(4), 55-63.




  • There are currently no refbacks.

Copyright (c)

Share us to:   


How to do online submission to another Journal?

If you have already registered in Journal A, then how can you submit another article to Journal B? It takes two steps to make it happen:

1. Register yourself in Journal B as an Author

Find the journal you want to submit to in CATEGORIES, click on “VIEW JOURNAL”, “Online Submissions”, “GO TO LOGIN” and “Edit My Profile”. Check “Author” on the “Edit Profile” page, then “Save”.

2. Submission

Go to “User Home”, and click on “Author” under the name of Journal B. You may start a New Submission by clicking on “CLICK HERE”.

We only use the following emails to deal with issues about paper acceptance, payment and submission of electronic versions of our journals to databases:;;;

 Articles published in Advances in Natural Science are licensed under Creative Commons Attribution 4.0 (CC-BY).


Address: 1055 Rue Lucien-L'Allier, Unit #772, Montreal, QC H3G 3C4, Canada.

Telephone: 1-514-558 6138
Website: Http://; Http://;

Copyright © 2010 Canadian Research & Development Centre of Sciences and Cultures