Special Topic: Noncoding DNA

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The special topic calls for papers on Noncoding DNA and such papers will appear in Advances in Natural Science as a special column.

Affiliated research area: Biology


In genetics, noncoding DNA describes components of an organism's DNA sequences that do not encode for protein sequences and was therefore sometimes referred to as "junk DNA". In many eukaryotes, a large percentage of an organism's total genome size is noncoding DNA, although the amount of noncoding DNA, and the proportion of coding versus noncoding DNA varies greatly between species. Much of this DNA has no known biological function and at one time was sometimes referred to as "Junk DNA". However, recent studies have shown that many types of noncoding DNA sequences do have known biological functions, including the transcriptional and translational regulation of protein-coding sequences. Other noncoding sequences have likely but as-yet undetermined function. In this special topic, we welcome scientific perspectives, reviews and original research papers on “Noncoding DNA” and its biological significance.


In addition to the Review and Original Articles by invited speakers, we are inviting you to submit a relevant research paper on Noncoding DNA for consideration. Papers will be subject to normal peer review and must comply with the Guide for Authors.

To submit papers to the “Noncoding DNA” Special Topic, please go to http://www.cscanada.net. With your submission, please state clearly to the editor that your manuscripts are submitted to the Special Topic Noncoding DNA.


Related Conferences:

June 02 - 07, 2013, University of New England, Nucleic Acids—Mechanistic Insights into DNA and RNA Metabolism throughout Biology

July 01 - 03, 2013 , Hinxton, Cambridge, UK, Working with the Human Genome Sequence

July 06 - 11, 2013, St Petersburg, Russia, 2013 (38th) FEBS Congress

July 07 - 12, 2013, Niagara, Canada, 10th International Conference on Intracellular RNA Localization and Localized Translation

March 18-23, 2012, Galveston, TX, Contribution of Sequenced Genomes to Understanding Behavior

Related Journals (Special issue):

Genes (Special Issue: Junk DNA' is not Junk)

Plant Systematics and Evolution (Special Issue: Molecular evolution and phylogenetic utility of non-coding DNA)


Related Articles:

Alexander, R. P., Fang, G., Rozowsky, J., Snyder, M., & Gerstein, M. B. (2010). Annotating non-coding regions of the genome. Nature Reviews Genetics, 11(8), 559-571.

Andolfatto, P. (2005). Adaptive evolution of non-coding DNA in Drosophila. Nature, 437(7062), 1149-1152.

Biémont, C., & Vieira, C. (2006). Genetics: junk DNA as an evolutionary force. Nature, 443(7111), 521-524.

Benko, S., Fantes, J. A., Amiel, J., Kleinjan, D. J., Thomas, S., Ramsay, J., ... & Lyonnet, S. (2009). Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence. Nature genetics, 41(3), 359-364.

Glazko, G. V., Koonin, E. V., Rogozin, I. B., & Shabalina, S. A. (2003). A significant fraction of conserved noncoding DNA in human and mouse consists of predicted matrix attachment regions. Trends in Genetics, 19(3), 119-124.

Kleine, T., Maier, U. G., & Leister, D. (2009). DNA transfer from organelles to the nucleus: the idiosyncratic genetics of endosymbiosis. Annual review of plant biology, 60, 115-138.

Musunuru, K., Strong, A., Frank-Kamenetsky, M., Lee, N. E., Ahfeldt, T., Sachs, K. V., ... & Rader, D. J. (2010). From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature, 466(7307), 714-719.

Mattick, J. S. (2009). The genetic signatures of noncoding RNAs. PLoS genetics, 5(4), e1000459.

Mercer, T. R., Dinger, M. E., & Mattick, J. S. (2009). Long non-coding RNAs: insights into functions. Nature Reviews Genetics, 10(3), 155-159.

Mahy, N. L., Perry, P. E., Gilchrist, S., Baldock, R. A., & Bickmore, W. A. (2002). Spatial organization of active and inactive genes and noncoding DNA within chromosome territories. The Journal of cell biology, 157(4), 579-589.

Nei, M., Suzuki, Y., & Nozawa, M. (2010). The neutral theory of molecular evolution in the genomic era. Annual review of genomics and human genetics, 11, 265-289.

Parker, S. C., Hansen, L., Abaan, H. O., Tullius, T. D., & Margulies, E. H. (2009). Local DNA topography correlates with functional noncoding regions of the human genome. Science, 324(5925), 389-392.

Willingham, A. T., & Gingeras, T. R. (2006). TUF love for “junk” DNA. Cell, 125(7), 1215-1220.

Zheng, Y., Josefowicz, S., Chaudhry, A., Peng, X. P., Forbush, K., & Rudensky, A. Y. (2010). Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature, 463(7282), 808-812.